This is the future

Tech product cycles are mutually reinforcing interactions between platforms and applications. New platforms enable new applications, which in turn make the new platforms more valuable, creating a positive feedback loop. Smaller, offshoot tech cycles happen all the time, but every once in a while — historically, about every 10 to 15 years — major new cycles begin that completely reshape the computing landscape.

Read this shit. By Chris Dixon.

How Preventable Is Cancer?

Given this widely accepted view, it was surprising last year when one of the world’s leading cancer scientists, John Hopkins University researcher Bert Vogelstein, together with mathematician Cristian Tomasetti, claimed that cancer is much less preventable than we thought. In a widely reported study, they argued that unavoidable, random DNA mutations, which occur routinely in our cells even in the absence of carcinogens, are “the major contributors to cancer overall, often more important than either hereditary or external environmental factors.” Cancer is often due to, in their words, “bad luck.”

As evidence for their claim, Tomasetti and Vogelstein presented a striking correlation between the lifetime risk of certain cancers, and the number of times cells replicate in the body tissues where those cancers arise. Why is the number of cell replications important? Because each time a cell replicates, a new copy of our DNA is made, and random mutations inevitably occur in the process. These mutations can’t be prevented, no matter how carefully we avoid carcinogens—the biochemical machinery that copies our DNA is very good, but not perfect. So each time a cell replicates, there is a fresh opportunity to be unlucky, by picking up a harmful mutation. Tissues with more replicating cells, like skin and colon, are therefore much more likely to acquire a cancer-causing mutation than tissues with fewer replicating cells, like brain and bone. “No other environmental or inherited factors are known to be correlated in this way across tumor types,” Tomasetti and Vogelstein noted. The implication is that prevention won’t be effective for many cancers. Mutations happen, and we can’t do much about it. Instead, we should focus on better screening to detect cancers early, when they can be treated more successfully.

Origen: How Preventable Is Cancer? – Pacific Standard

Apple: a competitive advantage

At the center of all this is Srouji, 51, an Israeli who joined Apple after jobs at Intel and IBM. He’s compact, he’s intense, and he speaks Arabic, Hebrew, and French. His English is lightly accented and, when the subject has anything to do with Apple, nonspecific bordering on koanlike. “Hard is good. Easy is a waste of time,” he says when asked about increasingly thin iPhone designs. “The chip architects at Apple are artists, the engineers are wizards,” he answers another question. He’ll elaborate a bit when the topic is general. “When designers say, ‘This is hard,’ ” he says, “my rule of thumb is if it’s not gated by physics, that means it’s hard but doable.”


Origen: The Most Important Apple Executive You’ve Never Heard Of

#MustRead A Snapchat masterclass

This is the only shit you need to figure out if you are into digital, marketing, media… well, almost anything for the next 200 years, so take care of your future around speed, digital-only minds, data consumption…


BROOKE: Don’t Snapchat boys that you like first — wait until they Snapchat you.
ELSBITCH: You need to have more than 150 views on your Story.

I stopped them again.

ME: Wait. Really? I have like 30.
BROOKE: OMG!! 30?? Only NARPs have less than 150.
ME: What the hell is a NARP?
BROOKE: Nonathletic Regular Person. NARP.
ME: Ah. So…I’m basic?

Origen: Teenagers Are Much Better At Snapchat Than You

The most interesting elite sportsman in the world

This is where Norris has chosen to live while he tries to win a job in the Blue Jays’ rotation: in a broken-down van parked under the blue fluorescent lights of a Wal-Mart in the Florida suburbs. There, every morning, is one of baseball’s top-ranked prospects, doing pull-ups and resistance exercises on abandoned grocery carts. There he is each evening, making French press coffee and organic stir-fry on his portable stove. There he is at night, wearing a spelunking headlamp to go with his unkempt beard, writing in his “thought journal” or rereading Kerouac.

He has been here at Wal-Mart for long enough that some store employees have given him a nickname — “Van Man” — and begun to question where he’s from and what he might be doing. A few have felt so bad for him that they’ve approached the van with prayers and crumpled bills, assuming he must be homeless. They wonder: Is he a runaway teen? A destitute surfer? A new-age wanderer lost on some spiritual quest?

The truth is even stranger: The Van Man has a consistent 92-mile-an-hour fastball, a $2 million signing bonus, a deal with Nike and a growing fan club, yet he has decided the best way to prepare for the grind of a 162-game season is to live here, in the back of a 1978 Westfalia camper he purchased for $10,000. The van is his escape from the pressures of the major leagues, his way of dropping off the grid before a season in which his every movement will be measured, catalogued and analyzed.

The man in the van – ESPN